Efficiency of triple test cross for detecting epistasis with marker information

Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits

Epistasis, commonly defined as the interaction between multiple genes, is an important genetic component underlying phenotypic variation. Many statistical methods have been developed to model and identify epistatic interactions between genetic variants. However, because of the large combinatorial search space of interactions, most epistasis mapping methods face enormous computational challenges...

Detecting Epistasis in Genome-wide Association Studies with the Marginal EPIstasis Test

Epistasis, commonly defined as the interaction between multiple genes, is an important genetic component underlying phenotypic variation. Many statistical methods have been developed to model and identify epistatic interactions between genetic variants. However, because of the large combinatorial search space of interactions, most epistasis mapping methods face enormous computational challenges...

Triple Test Cross Analysis for Genetic Components of Salinity Tolerance in Spring Wheat

Soil salinity poses considerable and increasing problems for agriculture, and is receiving much attention from plant breeders. The identification of genes whose expression enables plants to adapt to and/or tolerate salt stress is essential for breeding programs, but little is known about the genetic mechanisms of traits in saline conditions. The data obtained from 75 families produced by crossi...

Comparison of Micro Neutralization Test with Hemadsorption-Inhibition Test, and Immunoflrorescence Technique for Detecting Mumps Antibodies

Unraveling epistasis with triple testcross progenies of near-isogenic lines.

Libraries of near-isogenic lines (NILs) are a powerful plant genetic resource to map quantitative trait loci (QTL). Nevertheless, QTL mapping with NILs is mostly restricted to genetic main effects. Here we propose a two-step procedure to map additive-by-additive digenic epistasis with NILs. In the first step, a generation means analysis of parents, their F(1) hybrid, and one-segment NILs and th...